The Manitoba Follow-up Study, now in its 62nd year, is Canada's largest and longest running investigation of cardiovascular disease. Housed at the University of Manitoba since its inception on July 1, 1948, MFUS has followed a cohort of 3,983 healthy young men with annual contact and routine medical examinations amassing a database with which to study the natural history of cardiovascular disease. MFUS is ongoing - as of June 2009, 770 of the original cohort of 3,983 men are alive, at a mean age of 88 years. While analysis of electrocardiographic abnormalities, blood pressure patterns and heart disease continue, parallel analyses are being initiated to investigate issues concerning relationships between successful aging, functioning, and health.